CALL FOR PAPERS Small Vessels–Big Problems: Novel Insights into Microvascular Mechanisms of Diseases Sexually dimorphic phenotype of arteriolar responsiveness to shear stress in soluble epoxide hydrolase-knockout mice
نویسندگان
چکیده
Jun Qin, Sharath Kandhi, Ghezal Froogh, Houli Jiang, Meng Luo, Dong Sun, and An Huang Department of Physiology, New York Medical College, Valhalla, New York; Department of Pharmacology, New York Medical College, Valhalla, New York; Renji Hospital, Shanghai Jiaotong University School of Medicine, People’s Republic of China; Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, People’s Republic of China
منابع مشابه
Design, Synthesis and Biological Activity of 4,6-disubstituted Pyridin-2(1H)-ones as Novel Inhibitors of Soluble Epoxide Hydrolase
Soluble epoxide hydrolase enzyme is a promising therapeutic target for hypertension, vascular inflammation, pain and some other risk factors of cardiovascular diseases. The most potent sEH inhibitors reported in the literature are urea-based ones which often have poor bioavailability. In this study, in a quest for finding potent inhibitors of soluble epoxide hydrolase, some 4,6-disubstituted py...
متن کاملDesign, Synthesis and Biological Activity of 4,6-disubstituted Pyridin-2(1H)-ones as Novel Inhibitors of Soluble Epoxide Hydrolase
Soluble epoxide hydrolase enzyme is a promising therapeutic target for hypertension, vascular inflammation, pain and some other risk factors of cardiovascular diseases. The most potent sEH inhibitors reported in the literature are urea-based ones which often have poor bioavailability. In this study, in a quest for finding potent inhibitors of soluble epoxide hydrolase, some 4,6-disubstituted py...
متن کاملCALL FOR PAPERS Small Vessels–Big Problems: Novel Insights into Microvascular Mechanisms of Diseases Brief serotonin exposure initiates arteriolar inward remodeling processes in vivo that involve transglutaminase activation and actin cytoskeleton reorganization
Christopher A. Foote, Jorge A. Castorena-Gonzalez, Marius C. Staiculescu, Philip S. Clifford, Michael A. Hill, Gerald A. Meininger, and Luis A. Martinez-Lemus Dalton Cardiovascular Research Center, and Department of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri; Department of Biological Engineering, University of Missouri-Columbia, Columbia, Missouri; ...
متن کاملDesign, Synthesis and Biological Evaluation of 4-Benzamidobenzoic Acid Hydrazide Derivatives as Novel Soluble Epoxide Hydrolase Inhibitors
Inhibitors of soluble epoxide hydrolase (sEH) represent one of the novel pharmaceutical approaches for treating hypertension, vascular inflammation, pain and other cardiovascular related diseases. Most of the potent sEH inhibitors reported in literature often suffer from poor solubility and bioavailability. Toward improving pharmacokinetic profile beside favorable potency, two series of 4-benza...
متن کاملDesign, Synthesis and Biological Evaluation of 4-Benzamidobenzoic Acid Hydrazide Derivatives as Novel Soluble Epoxide Hydrolase Inhibitors
Inhibitors of soluble epoxide hydrolase (sEH) represent one of the novel pharmaceutical approaches for treating hypertension, vascular inflammation, pain and other cardiovascular related diseases. Most of the potent sEH inhibitors reported in literature often suffer from poor solubility and bioavailability. Toward improving pharmacokinetic profile beside favorable potency, two series of 4-benza...
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